Diakonos Research Ltd.

1110 Nasa Parkway Suite 108i

Houston, TX 77058

©2016 BY DIAKONOS RESEARCH LTD.

     

1.     Halpert MM, Vasquez-Perez J, Konduri V, Chen Y, Liang D, Levitt JM, Decker WK. Regulation and In Vivo Function of Dendritic Cell CTLA-4. To be presented at the American Association of Immunologists (AAI) 105th Annual Meeting, Austin, TX, May 4-8, 2018.

 

2.     Liang D, Tian L, You R, Halpert MM, Konduri V, Chen Y, Paust S, Kim D, Kim S, Jia F, Huang S, Zhang X, Kheradmand F, Corry DB, Gilbert BE, Levitt JM, Decker WK. AIMp1 is an essential regulator of the T-helper type 1 response. Cell Symposium Cancer, Inflammation, and Immunity, San Diego, CA, June 11-13, 2017.

 

3.     Douglass L, Halpert MM, Konduri V, Chen Y, Liang D, Levitt JM, Neal B, Hudson C, Hottinger H, Piscoya S, Wilson N, DiBernardi L, Stallings S, Omarbekov Z, Seelhoff L, Ramirez O, Yao QC, Bhardwaj RD, Ravi V, Decker WK. Active Specific Immunotherapy Mediates Durable Remission of Lethal Canine Hemangiosarcoma: A Model System for the Treatment of Angiosarcoma with Curative Intent. Published following the American Society of Clinical Oncology (ASCO) 53rd Annual Meeting, Chicago, IL, June 2-6, 2017.

 

4.     Konduri V*, Halpert MM, Chen Y, Liang D, Levitt JM, Neal B, Hudson C, Hottinger H, Piscoya S, Wilson N, DiBernardi L, Stallings S, Omarbekov Z, Seelhoff L, Ramirez O, Yao QC, Bhardwaj RD, Ravi V, Douglass L, Decker WK. Active Specific Immunotherapy plus Doxorubicin Chemotherapy Mediates Durable Remission of Lethal Canine Hemangiosarcoma. Orally presented at the American Association of Immunologists (AAI) 104th Annual Meeting, Washington, DC, May 12-16, 2017.

     *Platform Presentation Awardee

5.     Halpert MM, Konduri V, Chen Y, Liang D, Levitt JM, Neal B, Hudson C, Hottinger H, Piscoya S, Wilson N, DiBernardi L, Stallings S, Omarbekov Z, Seelhoff L, Ramirez O, Yao QC, Bhardwaj RD, Ravi V, Douglass L, Decker WK. Durable Remission of Lethal Canine Hemangiosarcoma. American Association of Cancer Research (AACR) 108th Annual Meeting, Washington DC, April 1 - 5, 2017.

 

6.     Konduri V, Halpert MM, Chen Y, Liang D, Levitt JM, Neal B, Hudson C, Hottinger H, Piscoya S, Wilson N, DiBernardi L, Stallings S, Omarbekov Z, Seelhoff L, Ramirez O, Yao QC, Bhardwaj RD, Ravi V, Douglass L, Decker WK. Durable Remission of Lethal Canine Hemangiosarcoma by Active Specific Immunotherapy. Presented at the 14th Annual Dan L. Duncan Cancer Center Symposium, Houston, TX, March 10, 2017.

 

7.    Tian S, Huang S, Kang X, Couturier, Arduino R, Decker WK, Kimata J, Rice A, Lewis D, Liu D. Potential Application of VRC01-CAR for Eradication of HIV-1 Reservoirs. Presented at the Harvard University Center for AIDS Research Strategies for an HIV Cure Symposium, Bethesda, MD, November 14-16, 2016.

 

8.    Konduri V, Li D, Halpert MM, Liang D, Liang Z, Hampton CN, Chen Y, Levitt JM, Yao QC, Decker WK. Low Dose Gemcitabine plus TH1 Dendritic Cell Vaccination Mediates Durable Cure of Orthotopic K-rasG12D/p53-/-Pancreatic Ductal Adenocarcinoma via the Generation of Atypical CD3+CD8+NK1.1+T-cells. Presented at the 13th Annual Dan L. Duncan Cancer Center Symposium, Houston, TX, November 6, 2015.

9.    Konduri V*+, Li D, Halpert MM, Liang D, Levitt JM, Yao QC, Decker WK. Low Dose Gemcitabine plus TH1 Dendritic Cell Vaccination Generates Durable Cure in a KrasG12D/p53-/- Orthotopic Model of Pancreatic Ductal Adenocarcinoma. Presented orally at the 46th Annual Meeting of the American Pancreatic Association, San Diego, CA, November 4-7, 2015.

      *Platform Presentation Awardee

      +2015 APA Award Recipient

 

10.     Konduri V, Li D, Halpert MM, Liang D, Liang Z, Hampton CN, Chen Y, Levitt JM, Yao QC, Decker WK. Low Dose Gemcitabine plus TH1 Dendritic Cell Vaccination Mediates Durable Cure of Orthotopic K-rasG12D/p53-/- Pancreatic Ductal Adenocarcinoma via the Generation of Atypical CD3+CD8+NK1.1+ T-cells. Presented at the 13th Annual Dan L. Duncan Cancer Center Symposium, Houston, TX, November 6, 2015.

 

11.     Liang D, Halpert MM, Konduri V, Chen Y, Kim D, Kim S, Levitt JM, Decker WK. Multienzyme Aminoacyl tRNA Synthetase Component AIMp1/p43 as an Important TH1 Mediator. Presented at the American Association of Immunologists (AAI) 102nd Annual Meeting, New Orleans, LA, May 8-12, 2015.

 

12.     Konduri V, Halpert MM, Liang D, Levitt JM, Hotez P, Jones KM, Decker WK. Therapeutic Platform for Immunotherapy of Chagas Disease. Presented at the American Association of Immunologists (AAI) 102nd Annual Meeting, New Orleans, LA, May 8-12, 2015.

 

13.     Halpert MM, Liang D, Konduri V, Pautler RG, Klumpp SA, Bhardwaj RD, Levitt JM, Decker WK. Dendritic Cell Homologous Antigenic Loading Initiates AIMp1-Mediated TH1 Immunity. Presented at the American Association of Immunologists (AAI) 102nd Annual Meeting, New Orleans, LA, May 8-12, 2015.

 

14.     Halpert MM*, Konduri V, Liang D, Chen YC, Wing JB, Paust S, Levitt JM, Decker WK. Mature Dendritic Cells Secrete Functionally Active CTLA-4 in Microvesicles. Presented at the American Association of Immunologists (AAI) 102nd Annual Meeting, New Orleans, LA, May 8-12, 2015.

      *2015 AAI Awardee

 

15.     Konduri V, Li D, Halpert MM, Liang D, Levitt JM, Yao Q, Decker WK. Vaccination by Homologous Antigenic Loading Reduces Tumor Growth and Metastasis in an Orthotopic Model of Pancreatic Cancer. Presented at the 12th Annual Dan L. Duncan Cancer Center Symposium, Houston, TX, January 26, 2015.

 

16.     Liang D, Halpert MM, Konduri V, Chen Y, Levitt JM, Decker WK. The Role of Multi-Enzyme Aminoacyl tRNA Synthetase Complex Component AIMp1/p43 in TH1 Immunity. Presented at the 12th Annual Dan L. Duncan Cancer Center Symposium, Houston, TX, January 26, 2015.

 

17.     Bhardwaj R, Chakravadhanula M, Hampton C, Ozols V, Georges J, Decker W, Kodibagkar V. Autologous Dendritic Cell Vaccine to Combat Brain Tumors in Mice and Canines. Presented at the Society for Neuro-Oncology 19th Annual Scientific Meeting and Education Day, Miami, FL, November 13-16, 2014.

 

18.  Halpert MM, Decker WK. Homologous Antigenic Loading Regulates Cellular Immunity through AIMp1 Release: Implications for Cancer Immunotherapy. Orally presented at the XXIII Nikolas Symposium on The Histiocytoses, Athens, Greece, May 8-11, 2014.

 

19.  Bhardwaj R, Chakravadhanula M, Ozols V, Georges J, Carlson E, Hampton C, Decker W. Autologous dendritic cell vaccine to combat brain tumors in dogs and mice. Presented at the Society for Neuro-Oncology 4th Quadrennial Meeting of the World Federation of Neuro-Oncology in conjunction with the 18th Annual Meeting of the Society for Neuro-Oncology, San Francisco, CA, November 21-24, 2013.

 

20.  Halpert MM, Cloud-Carstens JL, Collinson-Pautz M, Liang V, Konduri V, Klump S, Bhardwaj R, Berens ME, Pautler R, Spencer DM, Levitt JM, Decker WK. Immunosurgical resection of host tissues mediated by a novel dendritic cell-based vaccine proficient in the promulgation of TH1 immunity by exploitation of the p43/sCTLA-4 axis. Presented at the American Association of Immunologists (AAI) 100th Annual Meeting, Honolulu, HI, May 3-7, 2013.

21.  Halpert MM, Cloud-Carstens JL, Collinson-Pautz M, Liang V, Konduri V, Klump S, Bhardwaj R, Berens ME, Pautler R, Spencer DM, Levitt JM, Decker WK. Immunosurgical resection of host tissues mediated by a novel dendritic cell-based vaccine proficient in the promulgation of TH1 immunity by exploitation of the p43/sCTLA-4 axis. Presented at the 10th Annual Dan L. Duncan Cancer Center Symposium, Houston, TX, November 13, 2012.

 

22.  Halpert MM, Spencer DM, Bhardwaj R, Berens ME, Decker WK. The Potential Role of the Multienzyme Aminoacyl-tRNA Synthetase Complex in Th-1 Immunity: Implications for Cancer Immunotherapy. Presented at the American Association of Cancer Research (AACR) 103rd Annual Meeting, Chicago, IL, March 31 – April 4, 2012.

 

23.  Klumpp SA, Sharp K, Safdar A, Bhardwaj RD, Berens ME, Gilbert BE, Carstens JL, Halpert MM, Spencer DM, Decker WK. Partial Immunovesiculectomy by Th-1 Dendritic Cell Vaccination: Implications for Immunotherapy of Solid Tumors.  Presented at the American Association of Cancer Research (AACR) 103rd Annual Meeting, Chicago, IL, March 31 – April 4, 2012.

 

24.  Klump SK, Sharp K, Safdar A, Bhardwaj RD, Berens ME, Gilbert BE, Carstens JL, Halpert MM, Spencer DM, Decker WK. Ablation of Peripheral Tolerance and Partial Immunovesiculectomy by Th-1 Dendritic Cell Vaccination.  Presented at the 9th Annual Dan L. Duncan Cancer Center Symposium, Houston, TX, November 29, 2011.

 

25.  Decker WK, Zabriskie R, Gilbert B, Safdar A. Characterizing Surface Marker Expression, In Vivo Migration, and Efficacy of rHA-loaded Dendritic Cell Vaccines. Presented at the 50th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy, Boston, MA, September 12-15, 2010.

 

26.  Decker WK. Optimizing Dendritic Cell Immunotherapy for Prophylactic Vaccination: Lessons from Cancer Immunotherapy Trials. Platform presentation at The International Immunocompromised Host Society 16th International Symposium on Infections in the Immunocompromised Host, Budapest, Hungary, June 27-30, 2010.

 

27.  Decker WK, Zabriskie R, Machado A, Gilbert B, Shapll EJ, Safdar A.  Dendritic Cell Vaccination Generates Protective Responses against Influenzavirus Infection: A Model of Effective Vaccination for Immunosuppressed Cancer and Hematopoietic Stem Cell Transplant Patients.  Presented at The International Immunocompromised Host Society 16th International Symposium on Infections in the Immunocompromised Host, Budapest, Hungary, June 27-30, 2010.

 

28.  Decker WK, Li S, Zabriskie R, Machado A, Gilbert B, Shapll EJ, Safdar A.  Dendritic Cell Vaccination Generates Protective Responses Against Influenzavirus Infection: A Model Explored for Effective Vaccination of Immunosuppressed Stem Cell Transplant and Cancer Patients.  Orally presented at The 20th European Congress of Clinical Microbiology and Infectious Diseases, Vienna, Austria, April 10-13, 2010.

 

29.  Decker W, Shpall E, Safdar A. An Umbilical Cord Blood (UCB) Model of Dendritic Cell (DC) Vaccine Demonstrates the Ex Vivo Generation of De Novo Strain-Specific T-Lymphocyte Responses against Influenza A H1N1, H5N1 & H7N7. Presented at the 49th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, CA, September 12-15, 2009.

 

30.  Decker WK, Shpall EJ, Safdar A. An Umbilical Cord Blood Model of Dendritic Cell Vaccination Demonstrates the Ex Vivo Generation of T-Lymphocyte Responses. Orally presented at the 19th European Congress of Clinical Microbiology and Infectious Diseases, Helsinki, Finland, May 16-19, 2009.

 

31.  Decker WK, Li S, Xing D, Robinson SN, Yang H, Steiner D, Shpall EJ, Bollard CM, Safdar A. Generation of HLA-Restricted T-Lymphocyte Responses against Recombinant Influenzavirus Hemagglutinin A/New Caledonia by an In Vitro Umbilical Cord Blood Model of Dendritic Cell Vaccination. Presented at the ASBMT/CIBMTR 2009 BMT Tandem Meetings, Tampa, FL, February 11-15, 2009.

 

32.  Decker WK, Xing D, Li S, Robinson SN, Yang H, Steiner D, Komanduri KV, Shpall EJ.  Th-1 Immunity is Regulated by Dendritic Cell Comparison of MHC Class I and Class II Antigens: Implications for Successful Immunotherapy of Neoplasia.  Orally presented at the International Society for Vaccines 2nd Global Vaccine Congress, Boston, MA, December 7-9, 2008.

 

33.  Safdar A, Decker WK, Li S, Shpall EJ. De Novo T-lymphocyte Responses against Baculovirus-Derived Recombinant Influenzavirus Hemagglutinin Generated by a Naive Umbilical Cord Blood Model of Dendritic Cell Vaccination. Presented at The American Society for Microbiology 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC, October 25-28, 2008.

 

34.  Decker WK, Xing D, Li S, Robinson SN, Yang H, Yao X, Segall H, McMannis JD, Komanduri KV, Champlin RE, Shpall EJ. Double Loading of Dendritic Cell MHC Class I and MHC Class II Enhances Correlates of T-Cell Immunity In Vitro via Amplification of T-Cell Help, Presented at The 9th International Congress on Dendritic Cells, Edinburgh, Scotland, September 16-20, 2006.

 

35.  Decker WK, Xing D, Segall H, Li S, Robinson SN, Yang H, Komanduri KV, Shpall EJ. Cell-Autonomous Upregulation of Dendritic Cell Immunocompetence is Antigen-Dependent, Presented at The 9th International Congress on Dendritic Cells, Edinburgh, Scotland, September 16-20, 2006.

 

36.  Decker WK, Xing D, Li S, Champlin RE, McMannis JD, Komanduri KV, Shpall EJ. Cell-Autonomous Upregulation of Dendritic Cell Immunocompetence is Antigen-Dependent, Presented at The American Society of Hematology (ASH) 47th Annual Meeting and Exposition, Atlanta, GA, December 10-13, 2005.

 

37.  Decker WK, Xing D, Li S, Robinson SN, Yang H, Niu T, Thomas MW, Segall H, McMannis JD, Champlin RE, Shpall EJ. Double Loading of Dendritic Cell MHC Class I and MHC Class II to Enhance Clinical Efficacy of Immunotherapy for Acute Myelogenous Leukemia, Orally presented at the 6th International Symposium and Expert Workshops on Leukemia and Lymphoma, Amsterdam, The Netherlands, March 17-19, 2005.

 

38.  Decker WK, Xing D, Li S, Robinson SN, Yang H, Thomas MW, Segall H, McMannis JD, Champlin RE, Shpall EJ. Double Loading of Dendritic Cell MHC Class I and MHC Class II with an AML Antigen Repertoire Enhances Primary and Secondary T-cell Responses In Vitro, Presented at The American Society of Hematology (ASH) 46th Annual Meeting and Exposition, San Diego, CA, December 4-7, 2004.​

1.     Liang D, Tian L, You R, Halpert MM, Konduri V, Baig YC, Paust S, Kim D, Kim S, Jia F, Huang S, Zhang X, Kheradmand F, Corry DB, Gilbert BE, Levitt JM, Decker WK (2018) AIMp1 Potentiates TH1 Polarization and is Critical for Effective Antitumor and Antiviral ImmunityFront Immunol, 8: 1801. PMID: 29379495 

 

2.     Zhang Y, Wang Y, Decker WK, Wang Z, Zimmerman M (2017) Adaptive Modulation of MHC Class I Expression and Immune Evasion to Cytotoxic Immunocytes in Cancer Cells. Int J Eng Appl Sci, 4: 13-17. 

 

3.     Zhang Y, Wang Y, Decker, WK, Wang Z, Zimmerman M (2017) Inhibition of Cancer Cell Immune Evasion by Combined Application of Cytotoxic T-Lymphocytes and Natural Killer CellsJ Transl Res, 1: 12-19. 

 

4.     Konduri V, Halpert MM, Liang D, Levitt JM, Cruz JV, Zhan B, Bottazzi ME, Hotez PJ, Jones KM*, Decker WK* (2017) Genetic Adjuvantation of a Cell-Based Therapeutic Vaccine for Amelioration of Chagasic Cardiomyopathy. Infect Immun,85: e00127-17. PMID: 28674032 

5.     TianL, Goldstein A, Wang H, Lo HC, KimIS, WelteT, Sheng K, Dobrolecki LE, ZhangX, Putluri N, Phung TL, Mani SA, Stossi F, Sreekumar A, Mancini MA, DeckerWK, Zong C, LewisMT, Zhang XH (2017). Mutual Regulation of Tumor Vessel Normalization and Immunostimulatory ReprogrammingNature,544: 250-254. PMID: 28371798 

6.     Decker WK, Hernandez Sanabria MH, da Silva RF, Angelo L, Guimarães F, Kheradmand F, Paust S (2017) Cancer Immunotherapy in Murine, Canine, and Patient Derived Xenograft Models. Invited Review Article. Front Immunol, 8, 829. PMID: 28824608 

 

7.     KonduriV, LiD, Halpert MM, LiangD, LiangZ, Chen Y, Fisher WE, Paust S, Levitt JM, Yao Q*, Decker WK* (2016) Chemo-ImmunotherapyMediates Durable Cure of Orthotopic KrasG12D/p53-/-Pancreatic Ductal Adenocarcinoma. Oncoimmunology, 5: e1213933. PMID: 27757308 

 

8.     Halpert MM*, Konduri V*, Liang D, Chen YC, Wing JB, Paust S, Levitt JM, Decker WK (2016) Dendritic Cell Secreted CTLA-4 Regulates the T-cell Response by Downmodulating Bystander Surface B7. Stem Cell Dev, 25: 774-787.PMID: 26979751 

       *Journal Cover Article

9.    Block KI et al and the Halifax Project Contributing Authors including Decker WK (2015) Designing a broad-spectrum integrative approach for cancer prevention and treatment. Invited Review Article. Semin Cancer Biol 35, S276-S304. PMID: 26590477 

10.   Liang V, Halpert MM, Konduri V, Decker WK (2015) Stepping out of the cytosol: AIMp1/p43 potentiates the link between innate and adaptive immunity. Review Article. Int Rev Immunol, 34, 367-381. PMID: 26325028 

11.     Konduri V*,Decker WK*, Halpert MM, Gilbert B, Safdar A (2013) Modeling Dendritic Cell Vaccination for Influenza Prophylaxis: Potential Applications for Niche Populations. J Infect Dis, 207: 1764-72. PMID: 23460750 

 

12.     Badhiwala J, Decker WK, Berens ME, Bhardwaj RD (2013) Clinical Trials in Cellular Immunotherapy for Brain/CNS Tumors, Invited Review Article. Expert Rev Neurother,13: 405-424. PMID: 23545055 

 

13.     Decker WK, Safdar A (2011) Cytokine Adjuvants for Vaccine Therapy of Neoplastic and Infectious Disease, Review Article. Cytokine Growth Factor Rev 22: 177-187. PMID: 21862380  

 

14.     Decker WK, Xing D, Li S, Robinson SN, Yang H, Steiner D, Komanduri K, Shpall EJ (2009) Th-1 Polarization is Regulated by Dendritic Cell Comparison of MHC Class I and Class II AntigensBlood 113, 4213-4223. PMID: 19171878 

 

15.    Ni X, Richmond H, Liao X, Decker WK, Shiue LH, Shpall E, Duvic M (2008) Induction of T-cell Responses against Cutaneous T-cell Lymphomas ex vivoby Autologous Dendritic Cells Transfected with Amplified Tumor mRNA. J Invest Dermatol 128, 2631-2639. PMID: 18480841 

16.     Decker WK, Li S, Xing D, Robinson SN, Yang H, Steiner D, Komanduri KV, Bollard CM, Shpall EJ (2008) Deficient Th-1 Responses from TNFα-Matured and αCD40-Matured Dendritic Cells, J Immunother 31, 157-165. PMID: 18481385

17.     Decker WK, Shpall EJ (2008) Progress in Dendritic Cell Immunotherapy: Elucidating the Enigma of Th-1 Polarization, Invited Commentary, Hum Vacc 4,162-164. PMID: 18382128

18.    Xing D, Decker WK, Li S, Robinson SN, Yang H, Segall H, O’Connor S, Yao X, Komanduri KV, McMannis JD, Jones RB, Champlin RE, Shpall EJ (2006) AML-loaded DC generate Th1-type cellular immune responses in vitroCytotherapy 8, 95-104. PMID: 16698683 

19.    Decker WK, Xing D, Li S, Robinson SN, Yang H, Yao X, Segall H, McMannis JD, Komanduri KV, Champlin RE, Shpall EJ (2006) Double Loading of Dendritic Cell MHC Class I and MHC Class II with an AML Antigen Repertoire Enhances Correlates of T-cell Immunity In Vitro via Amplification of T-cell HelpVaccine 24, 3203-3216. PMID: 16480795 

20.    Decker WK, Xing D, Shpall EJ (2006) Dendritic Cell Immunotherapy for the Treatment of Neoplastic Disease, Invited Review Article, Biol Blood Marrow Transplant 12, 113-125. PMID: 16443510