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Redefining the Potential of Immunotherapy

Dentritic
Cell Vaccines

Developed at the Texas Medical Center, DOC1021 represents a novel approach to fighting cancer that harnesses the body’s natural anti-viral immune response.

At the core of DOC1021 is Diakonos’ proprietary “double-loading” technique. This patented process tricks the body into perceiving cancer cells as virally infected cells, mirroring the natural detection and elimination process for viral infections.
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Groundbreaking
Discovery on the
Immune System

DOC1021 is based on a discovery on how dendritic cells are able to detect and respond to viral threats. Based on Diakonos’ research, it is now known that dendritic cells compare antigens presented on MHC Class 1 and 2.

When identical antigens are detected on both MHC Class 1 and 2, dendritic cells mobilize formidable CD8 CD161 T cells to destroy what the immune system believes are infected cells throughout the body.
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Diakonos Oncology

News & Media

Diakonos Oncology’s Unique Dendritic Cell Vaccine (DOC1021) Improves Survival Compared to Standard of Care in Phase 1 Trial for Glioblastoma

Diakonos Oncology’s Unique Dendritic Cell Vaccine (DOC1021) Improves Survival Compared to Standard of Care in Phase 1 Trial for Glioblastoma

12/16 newly diagnosed GBM patients remain alive with no attributable serious adverse events at average of 12.9 months of follow up. Current 12-month overall survival of 88% for unmethylated GBM patients compares favorably to 53% 12-month historical survival of unmethylated GBM patients treated with standard of care The data were presented in a poster at […]

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Diakonos Oncology Appoints Biotech Veteran Anthony Baldor as Chief Financial Officer

Diakonos Oncology Appoints Biotech Veteran Anthony Baldor as Chief Financial Officer

HOUSTON–(February 26, 2024)–Diakonos Oncology Corp. (“Diakonos”), a clinical stage immuno-oncology company, announced today that Anthony Baldor has been appointed Chief Financial Officer. Mr. Baldor brings 20 years of financial management experience in the biotech industry including fundraising, business development, and corporate strategy. Mr. Baldor comes to Diakonos from 4D Molecular Therapeutics where he played critical […]

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Diakonos Oncology Names Paul Lammers, M.D., Veteran BioPharma Senior Executive, to its Board of Directors

Diakonos Oncology Names Paul Lammers, M.D., Veteran BioPharma Senior Executive, to its Board of Directors

HOUSTON–(February 20, 2024)–Diakonos Oncology Corp. (“Diakonos”), a clinical stage immuno-oncology company, announced today that Paul Lammers, M.D., M.Sc., a distinguished executive with over 35 years of experience in the biotech and pharmaceutical industries, has been named to its Board of Directors. “Dr. Lammers’ success in leading both private and public biopharma companies, combined with his […]

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Clinical Trials

Underway

Discover our treatment centers and find out which one is best for you.

Baylor College of MedicinePhase 1, NCT04157127

Pancreatic Adenocarcinoma

Baylor College of MedicinePhase 1, NCT04157127

Conducted in partnership with the Baylor College of Medicine, this phase 1, first in man trial is to determine the safety, toxicity, and feasibility of delivering autologous Dendritic Cells (DCs) to Pancreatic Cancer patients as adjuvant therapy following completion of standard chemotherapy.
MD Anderson Cooper, UT Health Science Center<br /> Phase 1, NCT04552886

Glioblastoma

MD Anderson Cooper, UT Health Science Center
Phase 1, NCT04552886

Conducted in partnership with the MD Anderson Cooper Hospital, this is a single arm (non-randomized) first-in-man pilot study to evaluate the safety and feasibility of delivering a Diakonos loaded Dendritic Cell Vaccine in nine to twenty-four adult patients diagnosed with Glioblastoma (GBM) after undergoing neurosurgical tumor resection, and in whom a neuropathological diagnosis has been established.
MD Anderson<br /> Phase 1, Pending

Sarcoma

MD Anderson
Phase 1, Pending

Conducted in partnership with the MD Anderson, this is a single arm (non-randomized) first-in-man pilot study to evaluate the safety and feasibility of delivering a Diakonos loaded Dendritic Cell Vaccine in nine to twenty-four adult patients diagnosed with Sarcoma after undergoing Standard of Care.